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Review Article

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Ca2+ Mobilization

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Pages 163-184 | Published online: 10 Oct 2008
 

Abstract

Many physiological processes are controlled by a great diversity of Ca2 + signals that depend on Ca2 + entry into the cell and/or Ca2 + release from internal Ca2 + stores. Ca2 + mobilization from intracellular stores is gated by a family of messengers including inositol-1,4,5-trisphosphate (InsP3), cyclic ADP-ribose (cADPR), and nicotinic acid adenine dinucleotide phosphate (NAADP). There is increasing evidence for a novel intracellular Ca2 + release channel that may be targeted by NAADP and that displays properties distinctly different from the well-characterized InsP3 and ryanodine receptors. These channels appear to localize on a wider range of intracellular organelles, including the acidic Ca2 + stores. Activation of the NAADP-sensitive Ca2 + channels evokes complex changes in cytoplasmic Ca2 + levels by means of channel chatter with other intracellular Ca2 + channels. The recent demonstration of changes in intracellular NAADP levels in response to physiologically relevant extracellular stimuli highlights the significance of NAADP as an important regulator of intracellular Ca2 + signaling.

Abbreviations
ADPRC=

ADP-ribosyl cyclase enzyme family

cADPR=

cyclic adenosine disphosphate ribose

CICR=

Ca2 +-induced Ca2 + release

ER=

endoplasmic reticulum

InsP3=

D-myo-inositol-1,4,5-trisphosphate

HSR=

heavy sarcoplasmic reticulum

NAADP=

nicotinic acid adenine dinucleotide phosphate

SERCA=

sarco(endo)plasmic reticulum Ca2 +-ATPase

RuRed=

ruthenium red

RyR=

ryanodine receptor

Abbreviations
ADPRC=

ADP-ribosyl cyclase enzyme family

cADPR=

cyclic adenosine disphosphate ribose

CICR=

Ca2 +-induced Ca2 + release

ER=

endoplasmic reticulum

InsP3=

D-myo-inositol-1,4,5-trisphosphate

HSR=

heavy sarcoplasmic reticulum

NAADP=

nicotinic acid adenine dinucleotide phosphate

SERCA=

sarco(endo)plasmic reticulum Ca2 +-ATPase

RuRed=

ruthenium red

RyR=

ryanodine receptor

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