The Neuropeptide Y (NPY) Y2 Receptors Are Largely Dimeric in the Kidney, but Monomeric in the Forebrain

S. L. PARKER Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee, USA

M. S. PARKER Department of Molecular Cell Sciences, University of Memphis, Memphis, Tennessee, USA

A. M. ESTES Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee, USA

Y. Y. WONG Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee, USA

R. SAH Department of Psychiatry, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA

T. SWEATMAN Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee, USA

E. A. PARK Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee, USA

A. BALASUBRAMANIAM Department of Surgery, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA

F. R. SALLEE Department of Psychiatry, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA

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Abstract

The neuropeptide Y(NPY) Y2 receptors are detected largely as dimers in the clonal expressions in CHO cells and in particulates from rabbit kidney cortex. However, in two areas of the forebrain (rat or rabbit piriform cortex and hypothalamus), these receptors are found mainly as monomers. Evidence is presented that this difference relates to large levels of G proteins containing the Gi α -subunit in the forebrain areas. The predominant monomeric status of these Y2 receptors should also be physiologically linked to large synaptic inputs of the agonist NPY. The rabbit kidney and the human CHO cell-expressed Y2 dimers are converted by agonists to monomers in vitro at a similar rate in the presence of divalent cations.

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The Neuropeptide Y (NPY) Y2 Receptors Are Largely Dimeric in the Kidney, but Monomeric in the Forebrain

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The Neuropeptide Y (NPY) Y2 Receptors Are Largely Dimeric in the Kidney, but Monomeric in the Forebrain

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