An overview of the molecular and clinical significance of the angiopoietin system in leukemia

Abstract

The angiogenesis efficacy in solid tumors and hematological malignancies has been identified for more than twenty years. Although the exact role of angiogenesis in leukemia as a common hematological malignancy has not yet been extensively studied, its effect is demonstrated on the initiation and maintenance of a favorable microenvironment for leukemia cell proliferation. The angiopoietin family is a defined molecular mediator for angiogenesis, which contributes to vascular permeability and angiogenesis initiation. They participate in the angiogenesis process by binding to tyrosine kinase receptors (Tie) on endothelial cells. Considering the role of angiogenesis in leukemia development and the crucial effects of the Ang–Tie system in angiogenesis regulation, many studies have focused on the correlation between the Ang–Tie system and leukemia diagnosis, monitoring, and treatment. In this study, we reviewed the Ang–Tie system’s potential diagnostic and therapeutic effects in different types of leukemia in the gene expression level analysis approach. The angiopoietin family context-dependent manner prevents us from defining its actual function in leukemia, emphasizing the need for more comprehensive studies.

Keywords:

• Angiopoietin
• leukemia
• Tie receptor

Acknowledgements

The authors thank all the healthy individuals and the family members for their participation and support in this study.

Consent form

Not applicable.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The analyzed data sets generated during the study are available from the corresponding author on reasonable request (all shareable information is provided in the form of figures, tables and text).

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.