Kinetic and dynamic data of analgesics and NSAIDs drugs reduce 10X uncertainty factors

Abstract

The risk assessment process must use all available toxicological data and scientific evidence on the adverse effects of chemicals or drugs. The relationship between biological indicators and exposure or tissue burdens is determined by the pharmacokinetic and pharmacodynamic behavior of the chemical. The purpose of the present project was to investigate the use of pharmacokinetic and pharmacodynamic data in reducing the uncertainties in establishing exposure levels for some analgesics and non‐steroidal anti‐ inflammatory drugs (NSAIDs). Five pharmaceuticals were evaluated, namely: naproxen, acetaminophen, aspirin, ibuprofen and ketoprofen. The pharmacokinetic and pharmacodynamic parameters in inter‐ and intra‐species were evaluated. The composite factors for all the examined drugs were far less than 100. The present study indicated that the formation of data basis for different chemicals based on pharmacokinetic and pharmacodynamic behavior is important in setting up exposure levels, rather than the use of default uncertainty factors which are in many cases imprecise.

Key words:

• NSAIDs
• pharmacokinetics
• pharmacodynamics
• uncertainty factor

Notes

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