Investigation of the Complexation Between Quinidine Carbamate and the Enantiomers of 3‐Chloro‐1‐phenyl‐propanol by Circular Dichroism and UV Spectroscopy

Abstract

UV and circular dichroism spectroscopic measurements showed that the molecular interactions in hexane/ethyl‐acetate solutions between dihydroquinidine tert‐butylcarbamate, used as a model for the quinidine carbamate chiral selector (QD), and 3‐chloro‐1‐phenyl‐propanol are too weak to affect the corresponding spectra of these compounds. The weak interactions between QD and 3‐chloro‐1‐phenyl‐propanol are probably masked by the formation of self‐associated dimeric structures in solution.

Keywords:

• Chiral selector
• Enantiorecognition
• Job's method
• Mole‐ratio method

Acknowledgments

This work was supported in part by grant CHE‐02‐44693 of the National Science Foundation, by Grant DE‐FG05‐88‐ER‐13869 of the US Department of Energy, and by the cooperative agreement between the University of Tennessee and the Oak Ridge National Laboratory. We thank Norbert Maier and Wolfgang Lindner (Institute of Analytical Chemistry, University of Vienna, Austria) for the gift of a sample of dihydroquinidine tert‐butylcarbamate.