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Abstract
In earlier investigations, we evaluated the performance of thin‐layer chromatography as an analytical tool to study oscillatory instability of selected profens dissolved in 70% ethanol and dichloromethane. In this study, the solvent used to dissolve profens is changed to physiological salt. The purpose was to assess if the selected test profens [i.e., S‐(+)‐ibuprofen, S‐(+)‐naproxen, and R,S‐(±)‐2‐phenylpropionic acid] can undergo oscillatory transenantiomerization if dissolved in physiological salt. It is a commonly known fact that physiological salt is often drip‐infused into the human (or animal) body with the addition of a drug. Therefore, the question arises whether profen drugs dispensed as physiological salt solutions can undergo oscillatory transenantiomerization in this particular medium. The results of our study confirm that such a transformation is in fact possible.
Acknowledgment
The authors wish to thank Merck KGaA (Darmstadt, Germany) for supplying the TLC plates and the sample of S,R‐(±)‐2‐phenylpropionic acid used in our experiments.
