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Original Articles

Comparison of Multiparallel Microfluidic HPLC Instruments for High Throughput Analyses in Support of Pharmaceutical Process Research

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Pages 2185-2200 | Received 28 Feb 2006, Accepted 28 Mar 2006, Published online: 07 Feb 2007
 

Abstract

The Eksigent Express 800 8 channel and the Nanostream Veloce 24 channel microfluidic HPLC systems were compared for their utility in providing high throughput chromatographic analysis to support a growing demand in pharmaceutical process research. Criteria for success are discussed, a comparison of the two instruments is made, and results from a head to head evaluation using a variety of different analyte mixtures are presented.

Acknowledgments

We would like to thank F. Mannarino, J.E. Rehm, D.H. DuPont, and D. Rakestraw at Eksigent Technologies, and P. Patel and D. Boyd at Nanostream for their support in this study. We are grateful to RT‐RLC for providing funding to support this research.

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