Photopolymerized Sol‐Gel Monolithic Column for Capillary Electrochromatography (CEC) and CEC Coupled to Atmospheric Pressure Photoionization Mass Spectrometry

Jie Zheng Department of Chemistry, Center of Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia, USA

Syed A. A. Rizvi Department of Chemistry, Center of Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia, USA

Professor Shahab A. Shamsi Department of Chemistry, Center of Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia, USACorrespondence[email protected]

Jingguo Hou Department of Clinical Sciences and Administration, College of Pharmacy, University of Houston, Texas Medical Center, Houston, Texas, USA

Abstract

A sol‐gel photopolymerization procedure was adopted to prepare the monolith in a 100 µm I.D. UV‐transparent capillary using methacryloxy‐propyltrimethoxysilane as the monomer. The chromatographic behavior of the column is evaluated with two mixtures of neutral compounds, namely 16 polycyclic aromatic hydrocarbons (PAH), and 11 alkyl phenyl ketones. The feasibility of applying this column for the CEC‐APPI‐MS separation and detection of these compounds was investigated.

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Acknowledgments

Financial support for this project was provided by the National Institutes of Health (Grant No. GM 62314). The authors thank Dr. Christine Miller of Agilent Technologies for providing the CE‐APPI‐MS spacer and Ciba (Tarrytown, NY) for supplying Irgacure 1800. J.Z. is grateful for the fellowship provided by Molecular Basic of Disease Foundation at Georgia State University.

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Photopolymerized Sol‐Gel Monolithic Column for Capillary Electrochromatography (CEC) and CEC Coupled to Atmospheric Pressure Photoionization Mass Spectrometry

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Photopolymerized Sol‐Gel Monolithic Column for Capillary Electrochromatography (CEC) and CEC Coupled to Atmospheric Pressure Photoionization Mass Spectrometry

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