Abstract
Reversed‐phase adsorption liquid chromatography was used to successfully resolve diastereomers in a complex mixture of low molecular weight polystyrene oligomers. The separation was achieved by incorporating a two‐dimensional liquid chromatography system where the polystyrene oligomers were transported from the first dimensional column, a C18, to an adsorbent phase in the second dimension, a carbon clad zirconia (CCZ) column. Using this system up to 46 diastereomers, each consisting of eight configurational repeat units, were able to be resolved in ultra high separations.
Acknowledgments
One of the authors (CSM) wishes to acknowledge the receipt of a University of Western Sydney Postgraduate Award. This work was, in part, supported by a UWS Internal Research Award.