RETENTION MECHANISM OF NINE SOLUTES BY THE USE OF LINEAR SOLVATION ENERGY RELATIONSHIPS ON A C₁₈ COLUMN

Abstract

Linear solvation energy relationships are used to investigate the fundamental chemical interactions governing the retention of 9 aromatic solutes in 36 mobile phases in reversed phase liquid chromatography. The systems studied involve sodium dodecyl sulfate (0.03–0.09 M) and two kinds of ionic liquids (0.003–0.009 M), with 5 to 20% acetonitrile as mobile phase modifiers in water. The mechanism of retention in two kinds of additive were analyzed and compared. The results suggest that LSER formalism is able to reproduce adequately the experimental retention factors of the solutes studied in the different experimental conditions investigated.

Keywords:

• chromatographic retention
• ionic liquid
• linear solvation energy relationships
• modifier
• surfactant

ACKNOWLEDGMENT

This research was supported by Basic Science Research Program through the National Research Foundation (NFR) of Korea funded by the Ministry of Education, Science and Technology (2009-0072787).