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Abstract
A new reversed-phase liquid chromatographic (LC) method with ultraviolet diode-array detection (UV-DAD) has been developed and validated for analysis of methamphetamine and propranolol in tablet formulations. The compounds were separated on an XTerra RP 18 column with acetonitrile-50 mM pyrrolidine (pH 11.5) 50:50 (v/v) as mobile phase at flow rate of 1 mL/min. The analysis was performed with ultraviolet (UV) detection at 214 nm. The analysis time was <4 min. The calibration curves showed good linearity over the working concentration range of 0.075–0.6 mg/mL. The correlation coefficients were r 2 = ≥ 0.9998 in each case. The relative standard deviation values for intra- and inter-day precision studies were <1%. Statistical analysis of the data showed that the method is precise, accurate, reproducible, and selective for the analysis of methamphetamine and propranolol drugs. The method was successfully employed for the determination of methamphetamine and propranolol in commercially available propranolol tablet formulations.
Notes
a Applied concentration % of target.
b (n = 3) the coefficient of variation (%CV).