Abstract
Using RP-HPTLC and RP-HPLC and a methanol-water mixture as the mobile phase, eight new p-toluenesulfonyl-hydrazinothiazole and hydrazine-bis-thiazole derivatives were studied. The linear correlation between RMw, kW and methanol/water ratios showed high values, for the correlation coefficient R2. The chromatographic hydrophobic index ϕ0 was determined by using intercept and slope, the obtained values ranging between 60 and 98. A good linear correlation was obtained between RMw, log kw, and slope. The log P values were calculated using database (Toronto, Canada). The matrices were formed with RMw, log kw and log P and were subjected to principal component analysis (PCA). The best way to extract information from PCA was graphically, by plotting the obtained matrices. By analyzing the scores, the compounds can be grouped in two: the first group contains three compounds that have a phenyl moiety while the second group comprises other five compounds that contain: methyl, chlor-methyl, acetyl, and ethylic ester.