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Abstract
A novel method for a direct separation of the enantiomers of 2,6-diketopiperazine derivatives was devised. The enantiomers were separated by means of chromatography on reversed-phase (RP-HPLC) column with β-cyclodextrin as a chiral mobile phase additive and hydroxy acids as solubility enhancers. The effect of β-cyclodextrin concentration, hydroxy acids type on retention, and enantioseparation were investigated. It was found that the systems with high concentrations of β-cyclodextrin in the presence of hydroxy acids, especially DL-tartaric acid, improve enantioselectivity, while the presence of citric acid aggravates it.
ACKNOWLEDGMENT
The research for this article was partially supported by the European Union within European Regional Development Fund, through grant Innovative Economy (POIG.01.01.02-14-102/09).