Abstract
Bromopentafluorobenzene is a very important fine chemical intermediate, which is synthesized from pentafluorobenzoic acid via decarboxylation and bromination in correct order. In this paper the high-performance liquid chromatography (HPLC) method has been applied in the synthesis of bromopentafluorobenzene, the HPLC determination condition has been studied for the first time. The ODS-C18 (4.6 × 150 mm, 5 µm) column was used. The mobile phase was a mixture of acetonitrile–water–trifluoroacetic acid (55:45:0.05). The wavelength of determination was 254 nm. This method is accurate, simple and rapid, and suitable to laboratory and industry.
ACKNOWLEDGMENT
This work was supported by the Doctor Foundation of Zhanjiang Normal University (No. ZL0701).
Notes
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