Selective Sorption and Determination of Atenolol in Pharmaceutical and Biological Samples by Molecular Imprinting Using New Copolymer Beads as a Functional Matrix

Abstract

A molecular imprinting polymer (MIP) based on free-radical polymerization was prepared with allyl glycidyl ether/iminodiacetic acid as functional monomers and copper ion-atenolol as the template. The imprinted polymer was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, elemental analysis, and scanning electron microscopy. The MIP of agglomerated micro-particles with multipores was used for solid phase extraction (SPE). The imprinted polymer sorbent was selective for the template. The profile of atenolol uptake by the sorbent reflects good accessibility of the active sites in the imprinted polymer sorbent. In addition, the equilibrium adsorption data of atenolol by MIP were analyzed by isotherm models. The MIP–SPE was the most feasible technique for the extraction of atenolol up to 89.9% in the human plasma, up to 96.0% in human urine, and up to 95.3% in tablets where the recoveries were achieved.

Keywords:

• atenolol
• biological fluids
• drug extraction
• molecular imprinting polymer
• pharmaceutical sample
• solid phase extraction

Notes

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