Abstract
A review of applications of micellar liquid chromatography (MLC) with special stress upon micellar thin layer chromatography (MTLC) in drug discovery is given. MLC and MTLC are presented as valuable sources of information on the physicochemical properties (mainly lipophilicity) of solutes and as tools to predict their biological activity: interactions with biomembranes, blood-brain barrier permeability, plasma protein binding, volume of distribution, gastric, ocular and skin absorption, environmental toxicity and bioaccumulation. The results of modeling based on the MLC/MTLC descriptors are correlated with those obtained by other in vitro, in vivo or in silico techniques used to study bioavailability. The future prospects of MTLC application in drug discovery and safety assessments of environmentally hazardous compounds are discussed.
GRAPHICAL ABSTRACT
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Acknowledgements
This work was supported by an internal grant of the Medical University of Lodz no. 503/3-016-03/503-31-001.
Disclosure statement
The Authors declare that there is no conflict of interest related to the publication of this manuscript.