Views

CrossRef citations to date

Altmetric

Original Articles

Development of an UHPLC-MS/MS method for remifentanil quantification in a small plasma volume

Kate O’HaraClinical Pharmacology, School of Medicine and Public Health, University of Newcastle, Newcastle, Australia; Correspondence[email protected]

Jennifer J. SchneiderClinical Pharmacology, School of Medicine and Public Health, University of Newcastle, Newcastle, Australia;

Alison L. JonesUniversity of Wollongong, Wollongong, Australia; ;Illawarra Health & Medical Research Institute, Wollongong, Australia;

http://orcid.org/0000-0002-7090-2953

Ian M. R. WrightUniversity of Wollongong, Wollongong, Australia; ;Illawarra Health & Medical Research Institute, Wollongong, Australia; ;Hunter Medical Research Institute, Newcastle, Australia

Jennifer H. MartinClinical Pharmacology, School of Medicine and Public Health, University of Newcastle, Newcastle, Australia;

Peter GalettisClinical Pharmacology, School of Medicine and Public Health, University of Newcastle, Newcastle, Australia;

Abstract

Remifentanil is a short acting opioid currently used in anesthesia and as an analgesic. This paper describes a simple, fast HPLC-MS/MS methodology that allows detection of remifentanil in low volume plasma samples. Acetonitrile protein precipitation is used for sample extraction and clean up. The assay has a lower limit of detection of 0.25 ng/mL and a 3 min run time.

Graphical Abstract

KEYWORDS:

Disclosure statement

No potential conflict of interest was reported by the authors.

Table 1. Inter-day variability of QC's.

Download CSV Display Table

Table 2. Inter-day variability of standards.

Download CSV Display Table

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Development of an UHPLC-MS/MS method for remifentanil quantification in a small plasma volume

Table 1. Inter-day variability of QC's.

Table 2. Inter-day variability of standards.

Information for

Open access

Opportunities

Help and information

Development of an UHPLC-MS/MS method for remifentanil quantification in a small plasma volume

Abstract

Graphical Abstract

Disclosure statement

Table 1. Inter-day variability of QC's.

Table 2. Inter-day variability of standards.

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature