An overview of liquid chromatographic methods for analyzing new generation anti-epileptic drugs

Abstract

Pregabalin, Lacosamide, Rufinamide, Perampanel, Eslicarbazepine acetate, Brivaracetam, Cannabidiol, Stiripentol, Everolimus, Cenobamate, and Fenfluramine are drugs of the third generation of antiepileptic drugs registered by International Coalition of Medicine Regulatory Authorities between 2000 and 2021. There are 213 peer-reviewed papers on antiepileptic drug analysis in the literature over the last three decades (1990–2022) which were reviewed in this article to provide an extensive overview of liquid chromatography techniques used to determine antiepileptic drugs. These details were discussed on the basis of a matrix: additives that are used to prepare a dosage form, sample preparation technique, column, limits of detection and quantification, types of elution in chromatography (isocratic or gradient), and detector. This review article will provide vital information to the scientific community in order to identify the most appropriate approach for antiepileptic drug analysis and determination.

Graphical Abstract

Keywords:

• Anti-epileptic drugs
• epilepsy
• liquid chromatography
• separation

Correction Statement

This article has been corrected with minor changes. These changes do not impact the academic content of the article.

Acknowledgments

The authors would like to thank the Faculty of Science at Eskisehir Technical University and all those who have supported us and given us all the facilities necessary to accomplish this review article.