Advances on analysis methods of ginkgo biloba leaf extract

Abstract

Ginkgo biloba leaf extract (EGBL) is a valuable herbal extract. The main active ingredients are flavonoids, terpene lactones, organic acids and proanthocyanidins. In recent years, there have been many reports on the detection of the above active ingredients. In this paper, the analysis methods of chemical components in EGBL were reviewed, such as ultraviolet spectrophotometry, high-performance liquid chromatography, and quantitative nuclear magnetic resonance. The analysis methods of ginkgolic acids are also reviewed. Based on the current research progress, three suggestions are provided. Firstly, the quality marker research of EGBL needs to be strengthened. Secondly, more bioassay methods for EGBL quality control should be developed. Thirdly, it is necessary to strengthen the detection of proanthocyanidins in EGBL.

GRAPHICAL ABSTRACT

Keywords:

• Analytical methods
• ginkgo biloba leaf extract
• quality control

Additional information

Funding

This work was supported by the Science and Technology Project Zhejiang Province, China [2022C03142] and the Fundamental Research Funds for the Central Universities [226-2022-00226].