![Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/110819/TOC-Subject-Sample-2021-Physical-Sciences.jpg"})
Abstract
An HPLC method in an isocratic mode with electrochemical detection is applied to monitor the levels of catecholamines, tryptophan and their metabolites in cerebrospinal fluid within 15 min. The method of is reproducible, stable and sensitive and offers an opportunity to study alterations caused by physiological changes. Deprivation of food reduced the levels of dopamine and its metabolites and increased the level of noradrenaline in the cerebrospinal fluid of rats and subsequent ingestion of food or intra-peritoneal injection of cholecystokinin octapeptide restored the levels to those of freely fed rats.