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Abstract
A HPLC/DAD method for simultaneous screening of 27 neuroleptics is presented. After single-step liquid-liquid extraction at pH 9.5 using chloroform/2-propanol/n-heptane (60/14/26, v/v), the substances are eluted on a Novapak C18 4μm column, with metha-nol/tetrahydrofuran/pH 2.6 phosphate buffer (65/5/30, v/v) as the mobile phase. Full UV spectra from 200 to 400 nm are recorded on-line during the entire analysis and may be automatically compared to spectra stored in a library. The method is simple, rapid, reproducible under local conditions, and highly specific.