Resolution of Enantiomers with Achiral Phase Chromatography

Abstract

Resolution of enantiomers is of widely accepted importance. Since there have been sporadic reports on liquid chromatographic resolution of enantiomers using achiral stationary phase in conjunction with a mobile phase having no external chiral compound the present paper focuses on such achiral phase resolutions of enantiomers along with their possible explanations. At the same time it introduces to the present day practice of resolution of enantiomers by liquid chromatography which makes use of a chiral selector either bound to the stationary phase or added to the mobile phase. The mechanisms for chiral phase chromatographic methods are also discussed.