Characterization of Spherical Polymer Packings from N,N-Dialkyl Acrylamide for Reversed-Phase Liquid Chromatography

Abstract

Chemically stable and totally organic polymer packings were prepared using N,N-dialkyl acrylamide monomers and their chromatographic properties were investigated. The hydrophobic parts of polymer packings were composed of N-methyl N-octadecyl acrylamide and N,N'-dibutylhexane N,N'-diacrylamide was used as a crosslinking monomer. The hydrophobicity of the spherical particles was easily controlled varying by the monomer ratio in the suspension polymerization. As for RPLC behavior, the packings had no abnormal adsorption for ionic substances and showed no excessive retention and no peak tailing for carbonyl compounds, because the packings had no ionic groups or amide protons. In addition, the packings show better alkali-and acid-resistances than conventional polymer packings into which alkyl groups were introduced through ester bondings.