High-Performance Liquid Displacement Chromatography of Enantiomers on A Chiral Poly-L-Valyl-Based Stationary Phase

Abstract

A direct enantiomer separation according to the displacement mode of liquid chromatography has been developed on a silica-based stationary phase bearing as chiral selectors poly-L-valyl groups. Milligram amount resolution of DL-methionine β naphthylamide was accom plished on two analytical size columns using methanol-containing acetate buffer as the carrier and DL mande lie acid dissolved in the carrier as the displacer.