Separation of Small Molecules in the Presence of Proteins Using Conducting Polymer Stationary Phases

H. Ge Intelligent Polymer Research Laboratory Chemistry Department, University of Wollongong, P. O. Box 1144, Wollongong, New South Wales, 2500, Australia

K. Gilmore Intelligent Polymer Research Laboratory Chemistry Department, University of Wollongong, P. O. Box 1144, Wollongong, New South Wales, 2500, Australia

A. Ashraf Intelligent Polymer Research Laboratory Chemistry Department, University of Wollongong, P. O. Box 1144, Wollongong, New South Wales, 2500, Australia

C. O. Too Intelligent Polymer Research Laboratory Chemistry Department, University of Wollongong, P. O. Box 1144, Wollongong, New South Wales, 2500, Australia

G. G. Wallace Intelligent Polymer Research Laboratory Chemistry Department, University of Wollongong, P. O. Box 1144, Wollongong, New South Wales, 2500, Australia

Abstract

Polypyrrole has been found to be selective for basic organic compounds. In this work, separation of basic drugs in the presence of proteins was investigated. The results indicated that under reversed phase conditions proteins had no retention on polypyrrole while basic drugs did. Proteins eluted at dead time while high retention was observed for caffeine and theophylline. Therefore the presence of proteins did not affect the separation of basic drugs.

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Separation of Small Molecules in the Presence of Proteins Using Conducting Polymer Stationary Phases

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Separation of Small Molecules in the Presence of Proteins Using Conducting Polymer Stationary Phases

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