22
Views
20
CrossRef citations to date
0
Altmetric
Original Articles

Comparison of the Enantioselectivity of Phenethyl- and Naphthylethyl-Carbamate Substituted Cyclodextrin Bonded Phases

, , , , &
Pages 127-147 | Received 22 Jun 1992, Accepted 06 Jul 1992, Published online: 23 Sep 2006
 

Abstract

(R)-, (S)- and racemic-phenethylcarbamate substituted-β-cyclodextrin bonded stationary phases were prepared and evaluated for the high performance liquid chromatographic separation of enantiomers. The results were compared to corresponding separations on an (S)-(-)-l-(l-naphthyl)ethyl-carbamate substituted β-cyclodextrin bonded phase. Successful separations were obtained in the reversed-phase and normal phase modes as well as with mobile phases of intermediate polarity. Different mechanisms of separation seem to be operative for various classes of compounds, depending upon the polarity of the mobile phase. The columns act as a novel cyclodextrin phase in the reversed phase mode, π-complex-hydrogen bonding chiral stationary phase in the normal phase mode, and cellulosic-like-phase with polar organic solvents such as methanol. With different chromatographic modes, it resolves completely different sets of enantiomers thereby serving as several columns in one.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.