Computational Chemical Analysis of the Chiral Recognition of Binuclear Copper (II) of N-Salicylidene (R)-2-Amino-1,2-bis(2-butoxy-5-tert.butylphenyl)-3-phenyl-1-propanol in Liquid Chromatography

Toshihiko Hanai International Institute of Technological Analysis Health Research Foundation Institute Pasteur de Kyoto 5F, Hyakumanben, Sakyoku, Kyoto, 606, Japan; School of Pharmaceutical Sciences, Kitasato University Shirokane, Minatoku, Tokyo, 108, Japan

Hiroyuki Hatano International Institute of Technological Analysis Health Research Foundation Institute Pasteur de Kyoto 5F, Hyakumanben, Sakyoku, Kyoto, 606, Japan; School of Pharmaceutical Sciences, Kitasato University Shirokane, Minatoku, Tokyo, 108, Japan

Noriyuki Nimura International Institute of Technological Analysis Health Research Foundation Institute Pasteur de Kyoto 5F, Hyakumanben, Sakyoku, Kyoto, 606, Japan; School of Pharmaceutical Sciences, Kitasato University Shirokane, Minatoku, Tokyo, 108, Japan

Toshio Kinoshita International Institute of Technological Analysis Health Research Foundation Institute Pasteur de Kyoto 5F, Hyakumanben, Sakyoku, Kyoto, 606, Japan; School of Pharmaceutical Sciences, Kitasato University Shirokane, Minatoku, Tokyo, 108, Japan

Abstract

The chiral recognition of a binuclear copper (II) complex of N-salicylidene-(R)-2-amino-1,2-bis(2-butoxy-5-tert.-butylphenetyl)-3-phenyl-1-propanol was analyzed by computational chemical calculation. The difference in the final energy calculated by molecular mechanics indicated the elution order of enantiomers on this chiral selective molecule.

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Computational Chemical Analysis of the Chiral Recognition of Binuclear Copper (II) of N-Salicylidene (R)-2-Amino-1,2-bis(2-butoxy-5-tert.butylphenyl)-3-phenyl-1-propanol in Liquid Chromatography

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Computational Chemical Analysis of the Chiral Recognition of Binuclear Copper (II) of N-Salicylidene (R)-2-Amino-1,2-bis(2-butoxy-5-tert.butylphenyl)-3-phenyl-1-propanol in Liquid Chromatography

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