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Abstract
The enantioselectivity of various Pirkle-concept chiral stationary phases (CSPs) for the direct HPLC separation of chiral drugs is explored and discussed. Seven different CSPs are surveyed for their utility to separate enantiomeric pairs belonging to the following major pharmaceutical classes: cardiovascular medicines (antihypertensives, antiarrhythmics, antianginals, diuretics), adrenergic drugs (vasopressors), antiinflammatory and analgesic compounds, topical anesthetics, antihistaminics, and antimalarial therapeutics.