![Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/110819/TOC-Subject-Sample-2021-Physical-Sciences.jpg"})
Abstract
A stability indicating high performance liquid chromatography assay for ranitidine has been developed for the study of ranitidine in intravenous solutions. The assay is based on an isocratic mobile phase, a C18 reverse phase column, UV detection and utilizes an internal standard. The assay is shown to be accurate and precise over a range of ranitidine concentration commonly found in IV solutions. The mean inter- and intra-assay variability is low and retention times are stable. The assay separates ranitidine form ranitidine decomposition products produced at acidic and basic pH's.