Chiral Chromatographic Discrimination Ability of a Cellulose 3,5-Dimethylphenylcarbamate/10-Undecenoate Mixed Derivative Fixed on Several Chromatographic Matrices

Abstract

The properties as chiral selector in HPLC chiral stationary phases (CSPs) of a cellulose derivative bearing simultaneously 3,5-dimethylphenylamino carbonyl and 10-undecenoyl groups are described. This polysaccharide is reticulated (or bonded) on chromatographic supports such as silica gel, previously treated or not, graphite or alumina. The chiral stationary phases thus obtained are resistant to the usual solvents used in liquid chromatography and can be used on normal or reversed phase conditions.

The results obtained on the resolution of racemic compounds with these stationary phases depend on the nature of the support. The best results were obtained with the chiral stationary phase in which the cellulose derivative is bonded on allyl silica gel.