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Abstract
A rapid, specific and reliable high performance liquid chromatographic assay of flavoxamine maleate in tablets has been developed. Reversed-phase chromatography was conducted using a mobile phase of 0.05M ammonium acetate and acetonitrile, (40% v/v) and detection at 240nm. The recovery and coefficient of variation from six placebo tablets containing 100 mg of fluvoxamine maleate were 100.56% and 0.439% respectively. Relicate regression analyses of three standard plots in the concentration range of 0.5–12 mcg/ml obtained on three different days gave a correlation coefficient > 0.9997 and the coefficient of variation of the slopes < 0.1%. The assay was precise within day and between days as indicated by ANOVA test. The recoveries from 10 replicate tablets of two commercial tablets (50, 100mg) was 99.2, 101.8 and 100.3% of the label amount and their coefficients of variation were 1.854 and 1.119%.