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Abstract
A liquid chromatographic method has been developed to quantify phenolic compounds in various hospital disinfectant products. Each product contained two of the following three phenols: o-phenylphenol (OPP), p-tert-amylphenol (PTAP), and o-benzyl-p-chlorophenol (OBPCP). An isocratic mobile phase consisting of methanol and phosphate buffer was used in conjunction with a 5 cm column, which contained 3 micron C-18 packing material, to enact the separation of the phenolic compounds from each other and from product matrix components. Calibration curve data were generated for each phenolic compound to demonstrate linear response over the concentration range of interest. Spiked sample recovery studies were performed to assess the accuracy of the method for the analysis of the phenolic compounds in various product matrices. Finally, photodiode array generated spectra were used to demonstrate the homogeneity of the phenolic compound peaks.