Determination of Norgestimate in Serum by Automated High-Performance Liquid Chromatography and Subsequent Radioimmunoassay

F. A. Wong Department of Drug Metabolism, The R.W. Johnson Pharmaceutical Research Institute at Ortho Pharmaceutical Corporation, Route 202, Raritan, New Jersey, 08869

S. J. Juzwin Department of Drug Metabolism, The R.W. Johnson Pharmaceutical Research Institute at Ortho Pharmaceutical Corporation, Route 202, Raritan, New Jersey, 08869

N. S. Tischio Department of Drug Metabolism, The R.W. Johnson Pharmaceutical Research Institute at Ortho Pharmaceutical Corporation, Route 202, Raritan, New Jersey, 08869

S. C. Flor Department of Drug Metabolism, The R.W. Johnson Pharmaceutical Research Institute at Ortho Pharmaceutical Corporation, Route 202, Raritan, New Jersey, 08869

Abstract

A method is described for the specific determination of norgestimate in human serum at concentrations of 25 to 1000 pg/mL. The method is based on automated high-performance liquid chromatography and on subsequent radioimmunoassay. Validation of the method included demonstration of low procedural blanks, recoverably of added standard and low intra- and inter-assay variability.

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Determination of Norgestimate in Serum by Automated High-Performance Liquid Chromatography and Subsequent Radioimmunoassay

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Determination of Norgestimate in Serum by Automated High-Performance Liquid Chromatography and Subsequent Radioimmunoassay

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