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Abstract
A simple and specific high performance liquid chromatographic (HPLC) method is described for the determination of R-(+)- and S-(−)acebutolols.
The method is based on the derivatization of the hydroxyl and amino functions of acebutolol with N-benzyloxycarbonyl-L-phenyl-alanine and acetic anhydride, respectively. The resulting derivatives were separated on a reversed phase C-18 column and monitored with a UV detector, leading to a base line resolution of the diastereomeric derivatives of S-(−) and R-(+) acebutolols.
