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Abstract
Tacrolimus (FK 506) is an macrolide immunosuppressive agent which is widely used for management of transplant patients. The drug is potent at concentrations well below the concentration of cyclosporine for patient management, but like cyclosporine, FK 506 also shows side effects such as nephrotoxicity and neurotoxicity. Because FK 506 exhibits wide variation in pharmacokinetics and a narrow therapeutic range, therapeutic monitoring of the drug is essential. Concentration of FK 506 can be monitored by high performance liquid chromatography (HPLC), Enzyme Linked Immunoassay (ELISA), HPLC-ELISA, HPLC-Mass Spectrometry and Fluorescence Polarization (FP) Immunoassay.