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Abstract
A novel high-performance liquid chromatographic (HPLC) method is described for the determination of the alkaloid cuscohygrine [1,3-bis(1-methyl-2-pyrrolidinyl)-2-propanone] in air-dried leaves of Erythroxylum coca var. coca. The analysis was performed on a weak cation exchange HPLC column using a mobile phase consisting of MeOH: 0.05 M KH2PO4, pH 7 (75:25, v/v) and with UV detection at 220 nm. Cuscohygrine content was determined as 0.21–0.23% in E. coca leaves.