Analysis and Pharmacokinetics of Apomorphine in Rat Brain by Microdialysis Coupled with Microbore HPLC Electrochemical Detection

T. H. Tsai National Research Institute of Chinese Medicine, Department of Pharmacology, Taipei, 11221, Taiwan; Institute of Traditional Medicine National Yang-Ming University, Taipei, 11221, Taiwan

C. F. Chen National Research Institute of Chinese Medicine, Department of Pharmacology, Taipei, 11221, Taiwan

F. C. Cheng Veterans General Hospital, Department of Medical Research Taichung, Taichung, 407, Taiwan

K. W. Kuo Department of Biochemistry

T. R. Tsai Graduate Institute of Pharmaceutical Sciences Kaohsiung Medical College, Kaohsiung, 807, Taiwan

Abstract

The feasibility of an on-line microdialysis coupled with a sensitive microbore high performance liquid chromatography with electrochemical detection (HPLC-ED) system for the direct analysis of apomorphine was investigated. A microdialysis probe was inserted into the right striatum of male Sprague-Dawley rats, which had been administered apomorphine (10 mg/kg, i.v.).

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Analysis and Pharmacokinetics of Apomorphine in Rat Brain by Microdialysis Coupled with Microbore HPLC Electrochemical Detection

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Analysis and Pharmacokinetics of Apomorphine in Rat Brain by Microdialysis Coupled with Microbore HPLC Electrochemical Detection

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