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Abstract
A simple and rapid HPLC method for the determination of ciclopirox, octopirox, and pyrithiones in pharmaceutical or antidandruff formulations has been developed. HPLC was carried out on a Purospher® RP-18 endcapped column using acetonitrile-water containing 0.02 M ortophosphoric acid and 0.5 mM EDTA disodium salt, (68:32, v/v) as the mobile phase and UV detection at 305 or 340 nm. The extraction procedure has been validated analysing samples spiked with known amounts of the active principles. The recoveries were greater than 94% and the reproducibility was within 3%.