Development of an Indirect Reverse Phase Method for the Quality Assessment of an Acyl Halide

C. M. Machado Analytical Research Department, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, NJ, 07065-0914

S. M. Thomas Analytical Research Department, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, NJ, 07065-0914

D. F. Hegarty Analytical Research Department, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, NJ, 07065-0914

R. A. Thompson Analytical Research Department, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, NJ, 07065-0914

D. K. Ellison Analytical Research Department, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, NJ, 07065-0914

J. M. Wyvratt Analytical Research Department, Merck Research Laboratories Merck & Co., Inc., P.O. Box 2000, Rahway, NJ, 07065-0914

Abstract

An indirect reverse phase HPLC method to monitor low level impurities in an acyl halide, 3-phenylpropionyl chloride, is described. The method involves derivatization with aniline to form a stable N-anilide derivative followed by HPLC analysis. The selection of the derivatizing agent aniline was based on achieving similar detector responses for impurities relative to the 3-phenylpropionyl chloride. The method described is rugged, selective, and sensitive and provides an excellent way to assess the quality of acyl halides.

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Development of an Indirect Reverse Phase Method for the Quality Assessment of an Acyl Halide

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Development of an Indirect Reverse Phase Method for the Quality Assessment of an Acyl Halide

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