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Original Articles

Purification of Zopiclone by Preparative High Performance Liquid Chromatography

Pages 2689-2698 | Received 15 Jul 1997, Accepted 20 Nov 1997, Published online: 22 Aug 2006
 

Abstract

The zopiclone was obtained in a 99.5% pure form, and in good yield by preparative scale high performance liquid chromatography. Purification was from a complex reaction mixture. A reversed phase preparative scale HPLC column is used. This work demonstrates how kilogram quantities of pure material can be conveniently obtained using preparative HPLC, even when the components in a mixture are difficult to resolve.

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