Determination of Melatonin in Commercially Available Products by LCEC and LC/MS/MS

Fuming Xie Bioanalytical Systems, Inc., West Lafayette, IN, 47906

Philip Wong Bioanalytical Systems, Inc., West Lafayette, IN, 47906; Department of Chemistry, Purdue University, West Lafayette, IN, 47907

Kazuaki Yoshioka Bioanalytical Systems, Inc., West Lafayette, IN, 47906

R. Graham Cooks Department of Chemistry, Purdue University, West Lafayette, IN, 47907

Peter T. Kissinger Bioanalytical Systems, Inc., West Lafayette, IN, 47906; Department of Chemistry, Purdue University, West Lafayette, IN, 47907

Abstract

Simple and reliable methods for liquid chromatography/electrochemistry (LCEC) and LC/MS/MS with atmospheric pressure chemical ionization (APCI) have been developed for the determination of melatonin in commercially available products. The dissolution of melatonin from the melatonin-containing formulations was simply obtained by dissolving the tablets and capsules in 20% acetonitrile in 0.1 N perchloric acid with ultrasonication. The filtrate of the resultant solution was separated on a 1 × 150 mm C

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Determination of Melatonin in Commercially Available Products by LCEC and LC/MS/MS

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Determination of Melatonin in Commercially Available Products by LCEC and LC/MS/MS

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