Kinetic Investigation on the Degradation of Lorazepam in Acidic Aqueous Solutions by High Performance Liquid Chromatography

I. E. Panderi Division of Pharmaceutical Chemistry Department of Pharmacy, University of Athens Panepistimiopolis, Athens, 15771, Greece

H. A. Archontaki Laboratory of Analytical Chemistry Department of Chemistry, University of Athens Panepistimiopolis, Athens, 15771, Greece

E. E. Gikas Division of Pharmaceutical Chemistry Department of Pharmacy, University of Athens Panepistimiopolis, Athens, 15771, Greece

M. Parissi-Poulou Division of Pharmaceutical Chemistry Department of Pharmacy, University of Athens Panepistimiopolis, Athens, 15771, Greece

Abstract

A high performance liquid chromatographic method was developed for the kinetic investigation on the acidic hydrolysis of lorazepam in 0.01, 0.1, and 1.0 M hydrochloric acid solutions. In this study, the simultaneous determination of lorazepam and its main degradation product was performed on a reversed phase BDS C-8 column. The mobile phase consisted of a mixture of methanol: acetonitrile: buffer solution containing 0.005 M KH

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Kinetic Investigation on the Degradation of Lorazepam in Acidic Aqueous Solutions by High Performance Liquid Chromatography

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Kinetic Investigation on the Degradation of Lorazepam in Acidic Aqueous Solutions by High Performance Liquid Chromatography

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