Parametric Studies on the Determination of Enantiomerization Rate Constants from Liquid Chromatographic Data by Empirical Peak Shape Equations for Multi-Step Consecutive Reactions

Richard Thede Institute of Physical Chemistry, University of Greifswald, Soldtmannstrasse 23, Greifswald, D-17489, Germany

Detlef Haberland Institute of Physical Chemistry, University of Greifswald, Soldtmannstrasse 23, Greifswald, D-17489, Germany

Christine Fischer Institute of Organic Catalysis Research, University of Rostock, Germany

Elke Below Institute of Forensic Medicine, University of Greifswald, Germany

Stanley H Langer Department of Chemical Engineering, University of Wisconsin, Madison, Wisconsin

Abstract

On-column enantiomerization is a well documented and practically important special case of the occurrence of a reversible reaction in a chromatographic reactor. The present paper explains the possibility to obtain enantiomerization rate constants from liquid chromatographic data using analytical equations derived for multi-step consecutive reactions. The results are compared with results from a finite difference method, and the application to experimental data is demonstrated.

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Parametric Studies on the Determination of Enantiomerization Rate Constants from Liquid Chromatographic Data by Empirical Peak Shape Equations for Multi-Step Consecutive Reactions

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Parametric Studies on the Determination of Enantiomerization Rate Constants from Liquid Chromatographic Data by Empirical Peak Shape Equations for Multi-Step Consecutive Reactions

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