Development of the rectal dosage form with silver-coated glass beads for local-action applications in lower sections of the gastrointestinal tract

Abstract

Context: Recent findings indicating the anti-inflammatory action of silver preparations through modulation of the gut microbiota and apoptosis of inflammatory cells predestine silver use in inflammatory bowel disease (IBD).

Objective: The aim of our study was to validate the possibility of effective silver release from silver-coated glass beads for anti-inflammatory local application in the lower sections of the gastrointestinal (GI) tract.

Materials and methods: Silver-coated glass beads were prepared using magnetron method. Release of silver from the silver-coated glass bead surface was carried out in BIO-DIS reciprocating cylinder apparatus. Erosion of silver coating and indirect estimation of the silver release dynamics was assessed using scanning electron microscope. Rectal suppositories containing silver-coated glass beads were prepared using five different methods (M1–M5) and X-ray scanned for their composition.

Results and discussion: The XR microanalysis and the chemical composition analysis evidenced for a rapid (within 30 min) release of nearly 50% of silver from the coating of the glass beads, which remained stable up to 24 h of incubation. The most homogeneous distribution of beads in the entire volume of the suppository was obtained for formulation M5, where the molten base was poured into mold placed in an ice bath, and the beads were added after 10 s.

Conclusions: Our study is the first to present the concept of enclosing silver-coated glass beads in the lipophilic suppository base to attenuate inflammation in the lower GI tract and promises efficient treatment with reduced side effects.

Keywords:

• Silver-coated glass beads
• metallic silver layer
• gastrointestinal tract
• drug delivery
• inflammatory bowel disease
• suppository

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Medical University of Lodz [503/1-156-04/503-11-001 to JF]. Hubert Zatorski is the recipient of Diamentowy Grant Program of the Polish Ministry of Science and Higher Education [No. 0202/DIA/2015/44].