Use of cellulose acetate butyrate as a carrier for preparation of alcohol-resistant matrix tablet

Abstract

The objective of this study was to investigate cellulose acetate butyrate (CAB) as a carrier for extended-release alcohol-resistant matrix tablet. Powder blends were either directly compressed or granulated before compression. The drug release from CAB matrix tablet was robust to formulation/process parameters such as compression force (10−20 kN), granular size (0.15−1.40 mm), and drug content (50–70%). In addition, release medium variables such as ionic strength, pH, and agitation rate had no effect on the drug release. CAB matrix tablet was more robust than ethylcellulose matrix tablet; the release from CAB matrix tablet was not affected by ethanol content (up to 20% v/v) in the release medium irrespective of agitation. CAB is a promising polymer for formulating of alcohol-resistant extended-release matrix tablet.

Keywords:

• Cellulose acetate butyrate (CAB-553-0.4)
• drug release
• extended release
• matrix tablet
• alcohol-resistant

Disclosure statement

No potential conflict of interest was reported by the author(s).