An overview on recent approaches for colonic drug delivery systems

Abstract

Colon-targeted drug delivery systems have garnered significant interest as potential solutions for delivering various medications susceptible to acidic and catalytic degradation in the gastrointestinal (GI) tract or as a means of treating colonic diseases naturally with fewer overall side effects. The increasing demand for patient-friendly drug administration underscores the importance of colonic drug delivery, particularly through noninvasive methods like nanoparticulate drug delivery technologies. Such systems offer improved patient compliance, cost reduction, and therapeutic advantages. This study places particular emphasis on formulations and discusses recent advancements in various methods for designing colon-targeted drug delivery systems and their medicinal applications.

Graphical Abstract

Keywords:

• Colon
• colonic diseases
• colonic drug delivery systems
• innovative methods
• nanoparticles
• nanoparticulate drug delivery technologies

Author contributions

Concept: A.D.G., T.C.; Design: A.D.G., T.C.; Control: A.D.G., T.C.; Sources: A.D.G., T.C.; Materials: A.D.G., T.C.; Data Collection and/or Processing: A.D.G., T.C.; Analysis and/or Interpretation: A.D.G., T.C.; Literature Review: A.D.G., T.C.; Manuscript Writing: A.D.G., T.C.; Critical Review: A.D.G., T.C.; Other: A.D.G., T.C.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The authors reported there is no funding associated with the work featured in this article.