Formulations for Intermittent Release of Parathyroid Hormone (1-34) and Local Enhancement of Osteoblast Activities

Abstract

The objective of these studies was to develop simple, implantable devices that intermittently release PTH(1-34) and thus could be used for locally stimulating bone formation. The formulations were based on the association polymer system of cellulose acetate phthalate and Pluronic F-127. Release profiles for intermittent devices showed five discrete peaks, whereas sustained devices exhibited zero-order kinetics. Osteoblastic activity was greater for cells intermittently treated with PTH(1-34) compared to sustained exposure. These controlled release devices delivering PTH(1-34) in an intermittent manner may be useful for affecting osteoblast activities in a localized area.

Keywords:

• controlled release
• intermittent release
• parathyroid hormone (PTH)
• PTH(1-34)
• CAP/PF-127 association polymer

ACKNOWLEDGMENTS

This work was supported by the Kentucky Science and Education Foundation (KSEF-148-502-03-67) and the National Institutes of Health (AR048700).