Nasal administration of ondansetron using a novel microspheres delivery system

Abstract

Gellan gum microspheres of ondansetron hydrochloride, for intranasal delivery, were prepared to avoid the first pass metabolism as an alternative therapy to parentral, and to improve therapeutic efficiency in treatment of nausea and vomiting. The microspheres were prepared using conventional spray-drying method. The microspheres were evaluated for characteristics like particle size, incorporation efficiency, swelling ability, zeta potential, in-vitro mucoadhesion, thermal analysis, XRD study and in-vitro drug release. Treatment of in-vitro data to different kinetic equations indicated diffusion controlled drug delivery from gellan gum microspheres. The results of DSC and XRD studies revealed molecular amorphous dispersion of ondansetron into the gellan gum microspheres.

Keywords::

• Gellan gum
• microspheres
• spray-drying
• ondansetron hydrochloride
• nasal

Acknowledgments

The authors are thankful to Burzin and Leons, CPKelco division of the Monsanto Company (USA) and Niramaye Pharmaceuticals, Nasik, India, for gifting gellan gum and ondansetron hydrochloride, respectively. The authors are also grateful to Principal of R.C. Patel, Institute of Pharmaceutical Education and Research, Shirpur, for providing the necessary facilities to carry out this work. Declaration of interest: The authors report no conflicts of interest.