Abstract
Reaction conditions for the Suzuki–Miyaura cross‐coupling of unprotected halopurine nucleosides with arylboronic acids in aqueous media were investigated. A series of arylated purine nucleosides was prepared in water without an organic cosolvent, using either Pd(PPh3)4 or Pd(OAc)2/TPPTS as the catalyst.
Acknowledgment
We thank the University of East Anglia for a studentship, the Nuffield Foundation for financial support, and the EPSRC National Mass Spectrometry Service Centre, Swansea, for the recording of mass spectra.