Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 6, 1994 - Issue sup1
0
Views
1
CrossRef citations to date
0
Altmetric
Section 2. Nasal Dosimetry in Animals and Man: Mathematical and Physical Models

In Vivo Measurements of Uptake

Pages 99-111 | Published online: 07 Aug 2023
 

Abstract

To elucidate the key physiologic/biochemical factors that influence the dose of inspired vapors delivered to the nasal cavity during inhalation exposure, upper respiratory tract uptake of a variety of vapors has been investigated in several small rodents, including the mouse, rat, hamster, and guinea pig. For nonreactive vapors, uptake was found to be dependent on the inspiratory flow rate and solubility. Species differences in nasal non-reactive vapor uptake were observed among rodents, with uptake being least efficient in the hamster and guinea pig. Vapors that are substrates for mixed-function oxidase or nasal carboxylesterase were also studied. Pretreatment with metabolic inhibitors significantly decreased uptake of these vapors, indicating that in situ metabolism can exert a strong influence on vapor uptake. These results highlight the importance of nasal metabolism in influencing dosimetry in that site as well as the need to incorporate metabolic terms in mathematic models of nasal vapor uptake.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.